Methods for treating viral infection using il-28 and il-29

Details Methods for treating viral infection using il-28 and il-29 Methods for treating viral infection using il-28 and il-29

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 38/17 (2006.01) A61P 31/12 (2006.01) C07K 14/54 (2006.01)

Patent

CA 2503305

IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

On a décelé que IL-28A, IL-28B, IL-29 et certains de leurs mutants ont une activité antivirale sur un large éventail d'espèces virales. Particulièrement intéressante est l'activité antivirale démontrée sur les virus qui infectent le foi, comme le virus de l'hépatite B et le virus de l'hépatite C. En plus, IL-28A, IL-28B, IL-29 et leurs mutants n'ont pas l'activité d'anti-prolifération sur les cellules hématopoïétiques qui est observée dans le traitement par l'interféron. Sans les effets immunosupresseurs qui accompagnent le traitement par l'interféron, on utilisera IL-28A, IL-28B et IL-29 dans le traitement de patients présentant un déficit immunitaire pour les infections virales.

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