Methods for treating viral infections

A - Human Necessities – 61 – K

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Details

A61K 31/00 (2006.01) A61K 31/22 (2006.01) A61K 31/365 (2006.01) A61K 31/366 (2006.01) A61K 45/06 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2363088

The present invention relates to methods of treating a vertebrate, particularly a mammal and more particularly murine or human patient, suffering from one or more viral infections, or a cell line infected with one or more viral infections, said viral infections including but not limited to the infections of the following viruses: hepatitis C, HIV, hepatitis A, hepatitis B, hepatitis G, or hepatitis H, by administering to said patient infected with at least one of virus at least one statin or statin-like compound determined to have anti-viral activity according to the present invention, said anti- viral statin or statin-like compound being selected from the group consisting of: mevastatin, lovastatin, pravastatin, simvastatin, and the compounds disclosed in U.S. Patents Nos. 4,346,227, 4,448,979, 4,739,073. 5,273,995, 5,169,857, 5,006,530, and 5,401,746.

La présente invention concerne des méthodes pour traiter un vertébré, en particulier un mammifère, et plus spécifiquement un patient murin ou humain atteint d'une ou plusieurs infections virales, ou une lignée cellulaire infectée par une ou plusieurs infections virales. Ces infections virales sont par exemple des infections des virus suivants, sans toutefois se limiter à celles-ci: hépatite C, VIH, hépatite A, hépatite B, hépatite G ou hépatite H. Les méthodes de cette invention consistent notamment à administrer au patient infecté par au moins un des virus susmentionnés une statine ou un composé apparenté à la statine présentant une activité antivirale, cette statine ou ce composé apparenté à la statine pouvant être choisis dans le groupe constitué par: la mévastatine, la lovastatine, la pravastine, la simvastatine, et les composés décrits dans les brevets américains nos. 4,346,227, 4,448,979, 4,739,073, 5,273,995, 5,169,857, 5,006,530, et 5,401,746.

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