A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/155 (2006.01) A61K 31/13 (2006.01)
Patent
CA 2623203
Methods for treating viral infections using polyamine analogs, including mitoguazone (MGBG), are provided. In these methods, polyamine analogs destroy macrophages that act as viral reservoirs, facilitating the destruction of the viruses that dwell within the macrophages. Examples of viral infections that may be treated with the present methods include, but are not limited to, infections from human immunodeficiency viruses. These methods differ from previous methods of treatment using polyamine analogs, wherein the polyamine analogs were administered only as anti-tumor agents.
Méthodes de traitement d'infections virales au moyen d'analogues de polyamine, dont le mitoguazone (MGBG). Ces méthodes consistent à utiliser des analogues de polyamine pour détruire des macrophages qui agissent comme des réservoirs de virus, ce qui facilite la destruction des virus résidant dans les macrophages. Les méthodes de l'invention permettent de traiter notamment, mais pas uniquement, des infections transmises par des virus de l'immuno-déficience humaine. Ces méthodes différent des méthodes de traitement au moyen d'analogues de polyamine utilisées jusqu'alors dans la mesure ou lesdits analogues n'étaient administrés que comme agents anti-tumoraux.
Hadlock Kenneth G.
Mcgrath Michael S.
Mcfadden Fincham
Pathologica Llc
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