C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/88 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/51 (2006.01) C07K 7/04 (2006.01) C07K 14/47 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2225406
Peptides and peptide analogues of the 65 kD isoform of human glutamic acid decarboxylase are provided for use in the treatment and prevention of diabetes. Peptide analogues contain generally from one to three amino acid alterations. Peptides and analogues may be used to diagnose diabetes and detect a predisposition to diabetes.
La présente invention décrit des peptides et des analogues de peptides de l'isoforme 65 kD de décarboxylase d'acide glutamique chez l'homme, à utiliser dans le traitement et la prévention du diabète. Les analogues de peptides contiennent généralement de une à trois modifications d'acide aminé. Les peptides et analogues peuvent être utilisés dans le diagnostic du diabète et la détection d'une propension au diabète.
Conlon Paul J.
Gaur Amitabh
Leslie R. David G.
Ling Nicholas
Londei Marco
Gowling Lafleur Henderson Llp
Kennedy Institute Of Rheumatology
Neurocrine Biosciences Inc.
St. Bartholomew's Hospital Centre For Clinical Research
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