A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 31/197 (2006.01) A61K 31/198 (2006.01) A61K 31/41 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01) C07C 323/58 (2006.01) C07D 223/12 (2006.01) C07D 257/06 (2006.01)
Patent
CA 2494284
Therapeutic methods for the prevention ad treatment of conditions and diseases of the gastrointestinal tract involving an overproduction of nitric oxide by inducible nitric oxide synthase are described, the methods including administering to a subject in need thereof a therapeutically effective amount of a selective inhibitor of inducible nitric oxide synthase (iNOS). The methods also include the use of selective inhibitors of iNOs in combination with other therapeutic agents, including antimicrobial agents and antisecretory agents.
L'invention concerne des procédés thérapeutiques destinés à prévenir et à traiter des troubles et des maladies du tractus gastro-intestinal impliquant une surproduction d'oxyde nitrique par synthase d'oxyde nitrique inductible. Ces procédés consistent à administrer à un sujet le nécessitant, une quantité efficace sur le plan thérapeutique d'un inhibiteur sélectif de synthase d'oxyde nitrique inductible (iNOS). Les procédés de l'invention comprennent également l'utilisation d'inhibiteurs sélectifs de iNOS en combinaison avec d'autres agents thérapeutiques, notamment des agents antimicrobiens et des agents antisécrétoires.
Connor Jane R.
Manning Pamela T.
Pharmacia Corporation
Smart & Biggar
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