A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01)
Patent
CA 2581173
The present invention includes methods for treatment and prophylaxis of diseases, post-surgical disorders and bacterial infections associated with lactosylceramide. The methods generally provide for administration to a subject one or more compounds that alter the activity of VEGF pathway members, including LacCer synthase (GalT-V/VI), PECAM1, VEGFR, VEGF or related pathway members to treat a subject suffering from or susceptible to a condition caused or contributed to by VEGF. The present invention also relates to methods for detecting and analyzing compounds with therapeutic capacity to treat such condition.
L'invention concerne des méthodes pour un traitement et pour une prophylaxie de maladies, de troubles post-chirurgicaux et d'infections bactériennes associés au lactosylcéramide. Ces méthodes consistent généralement à administrer à un patient au moins un composé modifiant l'activité d'éléments de voie VEGF, comprenant une LacCer syntase (GalT-V/VI), PECAM1, VEGFR, VEGF ou des éléments de voie associés pour traiter un patient souffrant d'un trouble provoqué ou favorisé par VEGF, ou un patient prédisposé à un tel trouble. L'invention concerne également des méthodes pour détecter et pour analyser des composés présentant des effets thérapeutiques permettant de traiter un tel trouble.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Johns Hopkins University
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