A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2379171
The present invention relates to gene therapy methods for the treatment of human disease. More specifically, the invention is directed, in one embodiment, to methods for treating a subject with a hyperproliferative disease. In another embodiment, an adenoviral expression construct comprising a nucleic acid encoding a human MDA-7 protein under the control of a promoter operable in eukaryotic cells is administered to the patient with a hyperproliferative disease. The present invention thus provides a gene therapy for treating hyperproliferative disease by elevating the expression of MDA-7 resulting in inhibition of cell growth and induction of apoptosis in hyperproliferative cells.
L'invention concerne des méthodes de thérapie génique destinées au traitement de maladies de l'homme, et elle concerne notamment, dans un mode de réalisation, des méthodes de traitement d'un sujet souffrant d'une maladie hyperproliférative. Dans un autre mode de réalisation, on administre à un tel sujet une construction d'expression adénovirale comprenant un acide nucléique codant pour la protéine humaine MDA-7, sous la régulation d'un promoteur fonctionnant dans des cellules eucaryotes. L'invention concerne donc une thérapie génique destinée à traiter une maladie hyperproliférative, par élévation de l'expression de MDA-7, laquelle inhibe la croissance cellulaire et induit l'apoptose des cellules hyperprolifératives.
Chada Sunil
Mhashilkar Abner
Schrock Bob
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Introgen Therapeutics Inc.
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