Methods for treatment of multiple sclerosis using peptide...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2204147

The present invention is directed toward peptide analogs of human myelin basic protein. The peptide analog is at least seven amino acids long and derived from residues 83 to 99 of human myelin basic protein. The analogs are altered from the native sequence at least at positions 91, 95, or 97. Additional alterations may be made at other positions. Pharmaceutical compositions containing these peptide analogs are provided. The peptide analogs are useful for treating multiple sclerosis.

Cette invention concerne des analogues peptidiques de la protéine basique de la myéline humaine. Un analogue peptidique, qui présente une longueur d'au moins sept acides aminés, est dérivé des restes 83 à 99 de la protéine basique de la myéline humaine. Les analogues sont modifiés par rapport à la séquence native au moins au niveau des positions 91, 95 ou 97. D'autres modifications peuvent être effectuées au niveau d'autres positions. Des produits pharmaceutiques contenant ces analogues peptidiques sont décrits. Les analogues peptidiques sont utiles pour le traitement de la sclérose en plaques.

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