C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2205532
Peptide analogues of human myelin basic protein containing residues 87-99 are provided. Residue 91 of the peptide analogues is altered from the L-lysine residue found in the native protein to any other amino acid. Pharmaceutical compositions of the peptide analogues are provided. In addition, the peptide analogues are administered to patients with multiple sclerosis.
Des analogues peptidiques de la protéine basique de la myéline humaine comportant les positions 87 à 99 sont décrits. La position 91 des analogues peptidiques est modifiée: la L-lysine observée dans la protéine naturelle y est remplacée par tout autre acide aminé. Des produits pharmaceutiques contenant les analogues peptidiques sont décrits. En outre, les analogues peptidiques sont administrés à des patients atteints de sclérose en plaques.
Conlon Paul J.
Gaur Amitabh
Ling Nicholas
Steinman Lawrence
Board Of The Trustees Of The Leland Stanford Junior University (
Gowling Lafleur Henderson Llp
Neurocrine Biosciences Inc.
The Board Of Trustees Of The Leland Stanford Junior University
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