Methods for treatment of multiple sclerosis using peptide...

Details Methods for treatment of multiple sclerosis using peptide... Methods for treatment of multiple sclerosis using peptide...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2340327

The present invention is directed toward peptide analogs of human myelin basic protein. The peptide analog is at least seven amino acids long and derived from residues 83 to 99 of human myelin basic protein. The analogs are altered from the native sequence at least at positions 91, 95 or 97. Additional alterations may be made at other positions. Pharmaceutical compositions containing these peptide analogs are provided. The peptide analogs are useful for treating multiple sclerosis.

L'invention concerne les analogues peptidiques de la protéine de base de la myéline humaine. Cet analogue peptidique a une longueur d'au moins sept acides aminés et est dérivé des résidus 83 à 99 de la protéine de base de la myéline humaine. Ces analogues sont modifiés par rapport à la séquence d'origine au moins aux positions 91, 95 ou 97. D'autres modifications peuvent être effectuées en d'autres positions. L'invention concerne également des compositions pharmaceutiques contenant ces analogues peptidiques. Ces analogues peptidiques sont utiles pour le traitement de la sclérose en plaque.

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