A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/095 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/145 (2006.01) A61K 31/16 (2006.01) A61K 31/426 (2006.01) A61K 31/66 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2313089
The present invention relates to new uses of S-2(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by therapeutic agents, radiation treatment or diabetes. In particular, the invention provides a method for treating neurotoxicity and nephrotoxicity associated with the administration of chemotherapeutic agents.
Dans la présente invention, on divulgue de nouvelles utilisations du dihydrogénophosphorothioate de S-2-(3-aminopropylamino)éthyle (amifostine) et d'autres aminothiols pour traiter et inverser les toxicités dues à des agents thérapeutiques, à des traitements par irradiation ou au diabète. On divulgue en particulier une méthode de traitement de neurotoxicité ou néphrotoxicité associée à l'administration d'agents chimiothérapeutiques.
Alberts David S.
Kaplan Edward H.
Stogniew Martin
Medimmune Oncology Inc.
Osler Hoskin & Harcourt Llp
The Arizona Board Of Regents
U.s. Bioscience Inc.
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