A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2360106
The invention teaches methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to inhibit angiogenesis in combination with a therapeutic amount of anti-tumor immunotherapeutic agent, such as an anti-tumor antigen antibody/cytokine fusion protein having a cytokine and a recombinant immunoglobulin polypeptide chain sufficient to elicit a cytokine-specific biological response.
Cette invention concerne des méthodes de traitement de tumeurs simples ou métastasées chez un mammifère. Ces méthodes consistent à administrer à un mammifère atteint une dose thérapeutique d'un antagoniste suffisante pour inhiber l'angiogenèse, en combinaison avec une dose thérapeutique d'un agent immunothérapeutique anti-tumoral, par exemple une protéine de fusion cytokine/anticorps anti-antigène tumoral renfermant une cytokine et une chaîne polypeptidique d'immunoglobine recombinante suffisante pour induire une réponse biologique spécifique de la cytokine.
Cheresh David A.
Gillies Stephen D.
Lode Holger N.
Reisfeld Ralph A.
Cassan Maclean
Lexigen Pharmaceuticals Corporation
The Scripps Research Institute
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