Methods for universally distributing therapeutic agents to...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/48 (2006.01) A61K 9/00 (2006.01) A61K 9/52 (2006.01) A61K 45/00 (2006.01)

Patent

CA 2296056

A method for universally distributing a therapeutic agent, in an encapsulated form, to the brain of a subject using intrathecal administration, excluding the lumbar region, is described. Methods for treating stroke and/or Traumatic Brain Injury (TBI) are also described. The methods involve intrathecal administration into the cerebrospinal fluid of a subject, of a therapeutic agent in an encapsulated form. Pharmaceutical compositions intended for the amelioration of stroke and/or Traumatic Brain Injury (TBI) are also described. The pharmaceutical compositions comprise a therapeutic agent encapsulated in a pharmaceutically acceptable polymer, suitable for injection into the cerebrospinal fluid of a subject suffering from stroke and/or Traumatic Brain Injury (TBI).

L'invention concerne un procédé de distribution universelle d'un agent thérapeutique, sous forme encapsulée, au niveau du cerveau d'un sujet par voie intrathécale, à l'exception de la région lombaire. L'invention concerne également des procédés de traitement des accidents cérébrovasculaires et/ou des lésions traumatiques du cerveau. Ces procédés consistent à administrer de manière intrathécale un agent thérapeutique sous forme encapsulée dans le fluide céphalo-rachidien d'un sujet. L'invention concerne en outre des compositions pharmaceutiques destinées à éviter les accidents cérébrovasculaires et/ou les lésions traumatiques du cerveau. Ces compositions pharmaceutiques renferment un agent thérapeutique, encapsulé dans un polymère pharmaceutiquement acceptable, qui peut être injecté dans le fluide céphalo-rachidien d'un sujet sujets aux accidents cérébrovasculaires et/ou aux lésions traumatiques du cerveau.

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