Methods for up-regulating antigen expression in tumors

Details Methods for up-regulating antigen expression in tumors Methods for up-regulating antigen expression in tumors

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) G01N 33/574 (2006.01) A61K 38/21 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2497151

The invention provides methods of modulating tumor antigen associated (TAA) expression, and methods of modulating TAA expression in order to treat a tumor. More particularly, the invention provides methods of increasing an immune response against tumor cell. Methods include administering to a subject with a tumor an amount of IFN-.beta. receptor agonist and tumor associated antigen (TAA) sufficient to increase an immune response against the tumor cell.

L'invention concerne des procédé de modulation de l'expression d'antigène associé à une tumeur (TAA), et des procédés de modulation de l'expression TAA de façon à traiter une tumeur. Elle concerne, plus particulièrement, des procédés permettant d'augmenter une réponse immune contre une cellule tumorale. Ces procédés consistent à administrer à un sujet atteint d'une tumeur une quantité suffisante d'un agoniste de récepteur d'IFN-.beta. et d'un antigène associé à la tumeur (TAA) afin d'augmenter la réponse immune contre la cellule tumorale.

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