Methods for use of mpl ligands with primitive human stem cells

Details Methods for use of mpl ligands with primitive human stem cells Methods for use of mpl ligands with primitive human stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/0789 (2010.01) C12N 5/078 (2010.01) A61K 35/28 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C07K 14/575 (2006.01) C12N 5/10 (2006.01) C12N 15/86 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2236263

Myeloproliferative leukemia receptor (mpl) ligands, such as thrombopoietin, act on a primitive subpopulation of human stem cells having the characteristics of self-renewal and ability to give rise to all hematopoietic cell lineages. Thrombopoietin supports both megakaryocytic differentiation and primitive progenitor cell expansion of CD34+ and CD34 sub-populations (CD34+Lin-, CD34*Thy-1+Lin-, and CD34+Lin- Rh12310). Thrombopoietin also stimulates quiescent human stem cells to begin cycling. Thus, mpl ligands are useful for expanding primitive stem cells for restoration of hematopoietic capabilities and for providing modified human stem cells for gene therapy applications.

Des ligands du récepteur de la leucémie myoéloproliférative (mpl), tels que la thrombopoïétine, agissent sur une sous-population primitive de cellules souches humaines présentant des caractéristiques de se renouveler de manière autonome et de donner naissance à tous les lignages cellulaires hématopoïétiques. La thrombopoïétine apporte son concours à la fois à la différenciation mégakaryocytaire et à l'expansion des cellules souches primitives de CD34<+> et de sous-populations de CD34<+> (CD34<+>Lin<->, CD34<+>Thy-1<+>Lin<->, CD34<+>Lin<->Rh123<lo>). La thrombopoïétine stimule également des cellules souches humaines inactives afin que celles-ci commencent à proliférer. Ainsi, ces ligands sont utiles pour développer des cellules souches primitives aux fins de restauration de capacités hématopoïétiques et de constitution de cellules souches humaines modifiées destinées à des applications de thérapie génique.

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