Methods for using adamts-12, an integrin and metalloprotease...

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07H 21/04 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2493890

The present invention relates to methods for using a human A Disintegrin And Metalloprotease containing ThromboSpondin repeats (ADAM-TS). The invention also relates to methods for using polynucleotides encoding the metalloprotease. The invention relates to methods using the ADAM-TS polypeptides and polynucleotides as a target for diagnosis and treatment in metalloprotease-mediated or -related disorders. The invention further relates to drug-screening method using the ADAM-TS polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ADAM-TS polypeptides and polynucleotides. The invention further relates to antagonists identified by drug screening methods with the ADAM-TS polypeptides and polynucleotides as a target. The invention further related to methods of treating a subject suffering from a ADAM-TS associated disorder.

L'invention concerne des méthodes permettant d'utiliser une désintégrine et métalloprotéase humaine contenant des motifs thrombospondine (ADAM-TS) ; des méthodes permettant d'utiliser des polynucléotides codant pour la métalloprotéase ; des méthodes permettant d'utiliser des polypeptides et des polynucléotides ADAM-TS comme cible à des fins diagnostiques et thérapeutiques dans des affections médiées par métalloprotéase ou associées à des métalloprotéase ; une méthode de dépistage de médicaments utilisant des polypeptides et des polynucléotides ADAM-TS pour identifier des agonistes et des antagonistes à des fins diagnostiques et thérapeutiques ; des agonistes et des antagonistes basés sur ces polypeptides et ces polynucléotides ADAM-TS ; des agonistes et des antagonistes identifiés par des méthodes de dépistage de médicaments en utilisant ces polypeptides et ces polynucléotides ADAM-TS comme cibles ; des méthodes permettant de traiter un sujet souffrant d'une affection associée à ADAM-TS.

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