A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/14 (2006.01) A61P 7/00 (2006.01) A61P 7/06 (2006.01)
Patent
CA 2668608
The present invention relates to methods repairing, regenerating, and reconstituting tissues by transplanting at least two stem cell populations, wherein the first and the second population of stem cells are introduced into a subject separated by a time interval of about 2 to about 24 hours. The first population comprises stem cells derived from umbilical cord. The second population comprises ALDHbr cells. These ALDHbr cells can be administered to a patient immediately after isolation or can be primed in culture using a combination of cytokines for about 2 to about 7 days prior to transplantation. The methods of the invention are useful in accelerating time to neutrophil and/or platelet engraftment and immune reconstitution following myeloablative therapy.
La présente invention concerne des méthodes de réparation, de régénération et de reconstitution de tissus, consistant à transplanter au moins deux populations de cellules souches, ces dernières étant introduites dans un sujet séparément à un intervalle compris entre 2 et 24 heures environ. La première population comprend des cellules souches du cordon ombilical. La seconde population comprend des cellules ALDHbr. Ces cellules ALDHbr peuvent être administrées à un patient immédiatement après isolation ou peuvent être amorcées en culture à l'aide d'une combinaison de cytokines pendant 2 à 7 jours environ avant la transplantation. Les méthodes de l'invention sont utiles pour accélérer la prise de greffe des neutrophiles et/ou des plaquettes et la reconstitution immunitaire suivant la thérapie myéloablative.
Haley N. Rebecca
Kurtzberg Joanne
Aldagen Inc.
Duke University
Smart & Biggar
LandOfFree
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