Methods for using granzymes and binding molecules thereof...

Details Methods for using granzymes and binding molecules thereof... Methods for using granzymes and binding molecules thereof...

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 38/48 (2006.01) C12N 1/38 (2006.01) C12N 9/64 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2298867

A method for determining if an animal is at risk for a disease resulting in abnormal apoptosis is described. An animal is provided and an aspect of metabolism or structure of a serine protease, e.g., a granzyme, or a serine protease binding molecule in the animal is evaluated. An abnormality in the aspect of the metabolism or structure is diagnostic of being at risk for a disease resulting in abnormal apoptosis. Also described are methods for evaluating an agent for use in modulating apoptosis, methods for effecting or inhibiting apoptosis in a cell, and methods for treating unwanted cell or infectious particle proliferation or treating an autoimmune disease or a transplant graft rejection in an animal. Pharmaceutical compositions are also provided.

L'invention concerne un procédé permettant de déterminer si un animal est susceptible de présenter une maladie due à une apoptose anormale. Un aspect du métabolisme ou de la structure d'une sérine protéase; par exemple, une granzyme, ou une molécule de fixation de la sérine protéase, d'un animal est évalué. Toute anomalie de l'aspect du métabolisme ou de la structure permet de diagnostiquer une susceptibilité d'une maladie due à une apoptose anormale. L'invention traite également de procédés permettant d'évaluer un agent mis oeuvre pour moduler l'apoptose, de procédés pour effectuer ou inhiber l'apoptose dans une cellule, et de procédés pour traiter toute prolifération de particules infectieuses ou de cellules indésirables ou pour traiter toute maladie autoimmune ou tout rejet de greffon. L'invention concerne également des compositions pharmaceutiques.

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