Methods for using histamine derivatives as immunomodulators...

A - Human Necessities – 61 – K

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A61K 39/35 (2006.01) A61K 31/415 (2006.01) C07K 14/415 (2006.01) C07K 16/16 (2006.01)

Patent

CA 2128331

2128331 9313772 PCTABS00024 The present invention provides methods using histamine derivatives as immunomodulators and in immunotherapeutics. More specifically the present invention provides methods for inhibiting at least a portion of an antigen specific antibody response by the immune system of a mammal comprising administering to said mammal an effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor. The invention also pertains to methods of treating sensitivity to a particular antigen in an individual by administering to the individual a therapeutically effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor, and in conjunction therewith, optionally administering to the individual the antigen or the immunogenic or T-cell stimulating portion thereof to which the individual may be sensitive.

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