A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) A61K 49/04 (2006.01)
Patent
CA 2465793
New and sensitive methods for imaging the perfusion of tissues and the extravasation of blood out vessels have been developed. The present invention is useful in the imaging of microperfusion in organ tissues (e.g.), heart, liver, brain and kidneys) to aid in evaluating the perfusion status of organs on the level of the smallest blood vessels (i.e. capillaries). The present invention also provides methods and compositions for imaging and evaluating macrophages and plaque, e.g., vulnerable plaque. Such evaluations are important in a number of clinical diagnoses, including assessing organ damage associated with angina pectoris, heart attack, stroke, and the like, as well as assessing vessel leakages associated with aneurisms, diffuse bleedings after trauma, and the like.
L'invention concerne des procédés nouveaux et sensibles permettant la visualisation de la perfusion des tissus et l'extravasation du sang hors des vaisseaux sanguins. Ces procédés sont utilisés pour visualiser la microperfusion dans les tissus des organes (p. ex. coeur, foie, cerveau et reins), et faciliter ainsi l'évaluation de l'état de perfusion des organes à l'échelle des plus petits vaisseaux sanguins (p. ex. capillaires). L'invention concerne également des procédés et des compositions permettant la visualisation et l'évaluation des macrophages et des plages de lyse, p. ex. des plages de lyse sensibles. De telles évaluations sont importantes dans un grand nombre de diagnostics cliniques, notamment dans la détermination des lésions organiques associées à l'angine de poitrine, aux crises cardiaques, aux accidents vasculaires cérébraux, et pathologies analogues, ainsi que dans l'évaluation des fuites vasculaires associées aux anévrismes, des saignements diffus à la suite de traumatisme etc.
Koenig Reinhard
Williams Taffy
Borden Ladner Gervais Llp
Imcor Pharmaceutical Co.
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