C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/713 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2714997
The invention relates to methods involving MS4A12 and agents targeting MS4A12 which are useful for therapy, diagnosis and testing of disease states, in particular cancer diseases. In particular, the invention relates to agents which reduce or inhibit expression or activity of MS4A12, compositions containing these agents, and methods for reducing, determining, or increasing the responsiveness of a cell towards EGF.
L'invention porte sur des procédés mettant en jeu MS4A12 et des agents de ciblage de MS4A12 qui sont utiles pour la thérapie, le diagnostic et le test d'états pathologiques, en particulier de maladies cancéreuses. En particulier, l'invention porte sur des agents qui réduisent ou inhibent l'expression ou l'activité de MS4A12, sur des compositions contenant ces agents et sur des procédés de réduction, détermination ou augmentation de la réactivité d'une cellule vis-à-vis de l'EGF.
Koslowski Michael
Sahin Ugur
Tuereci Oezlem
Ganymed Pharmaceuticals Ag
Gowling Lafleur Henderson Llp
Johannes Gutenberg Universitaet Mainz
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