Methods, kits, and compounds for determining responsiveness...

Details Methods, kits, and compounds for determining responsiveness... Methods, kits, and compounds for determining responsiveness...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2690481

The invention provides methods, kits and compounds for determining the potential responsiveness of a subject suffering from a pathological disorder, including non-small cell lung cancer (NSCLC), to treatment with an epothilone by analyzing the gene expression profile and/or certain molecular markers in a sample obtained from said subject. The invention further relates to methods, compounds and uses of said compounds for treating subjects suffering from said pathologic disorder, optionally in combination with other therapeutic agents. Also provided are genes and/or proteins encoded by them whose expression level have been determined to differ between epothilone responders and epothilone non- responders.

L'invention porte sur des procédés, des trousses et des composés permettant de déterminer une sensibilité potentielle d'un sujet souffrant d'un trouble pathologique, y compris un cancer du poumon à grandes cellules (NSCLC), à un traitement par épothilone par l'analyse du profil d'expression génique et/ou de certains marqueurs moléculaires dans un échantillon obtenu à partir dudit sujet. L'invention porte en outre sur des procédés, des composés et des utilisations desdits composés pour traiter des sujets souffrant dudit trouble pathologique, facultativement en combinaison avec d'autres agents thérapeutiques. L'invention porte également sur des gènes et/ou des protéines codés par ceux-ci, dont le taux d'expression a été déterminé comme se distinguant entre répondeurs à l'épothilone et non-répondeurs à l'épothilone.

Affiliated with

Also associated with

Rating

Methods, kits, and compounds for determining responsiveness... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods, kits, and compounds for determining responsiveness..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods, kits, and compounds for determining responsiveness... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1774934