Methods, mixtures, kits and compositions pertaining to...

C - Chemistry – Metallurgy – 07 – D

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C07D 295/185 (2006.01) C07D 295/15 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2656295

This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination by mass spectrometry using labeling reagents that comprise a nucleophilic reactive group that reacts with a functional group of an analyte to produce a labeled analyte. The labeling reagents can be used as isobaric sets, mass differential labeling sets or in a combination of isobaric and mass differential labeling sets.

Les procédés, mélanges, trousses et compositions faisant l'objet de la présente invention portent sur la détermination d'analytes par spectrométrie de masse, à l'aide d'agents de marquage contenant un groupe nucléophile réactif qui réagit avec un groupe fonctionnel d'un analyte pour produire un analyte marqué. Les agents de marquage peuvent être utilisés en tant qu'ensembles de marquage isobare, ensembles de marquage par différence de masse ou ensembles de marquage isobare et par différence de masse combinés.

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