A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/618 (2006.01) A61K 36/45 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2512405
The present disclosure provides methods for obtaining gaultherin, a natural salicylate derivative, from plant tissue. The methods involve preventing the hydrolysis of the gaultherin in the plant tissue by disrupting the plant tissue under solvent conditions lacking a drying agent. The disclosure further provides various forms of plant-derived gaultherin, including alcoholic extracts aqueous solutions and dried preparations, all suitable for use as a natural aspirin substitute. Moreover, the disclosure provides methods of using gaultherin-containing compositions to increase serum salicylic acid, to treat cancer cells, to treat cardiovascular (e.g., cardiopulmonary) conditions, to treat anti-inflammatory responses, and to inhibit cyclooxygenase.
La présente invention porter sur des procédés visant à obtenir la gaulthérine, un dérivé de salicylate naturel, à partir d'un tissu végétal. Les procédés de l'invention consistent à prévenir l'hydrolyse de la gaulthérine dans le tissu végétal en rompant le tissu dans des conditions de solvant privées d'agent dessiccatif. L'invention porte également sur diverses formes de gaulthérine extraite des plantes, telles que des extraits alcooliques, des solutions aqueuses et des préparations lyophilisées, toutes ces formes étant appropriées pour être utilisées comme substitut naturel de l'aspirine. L'invention porte, en outre, sur des procédés d'utilisation de compositions contenant la gaulthérine pour augmenter l'acide silicique du sérum, pour traiter les cellules cancéreuses, les troubles cardio-vasculaires (cardio-pulmonaires), les réponses anti-inflammatoires et pour inhiber la cyclo-oxygénase.
Poulev Alexander A.
Raskin Ilya
Ribnicky David M.
Rutgers The State University Of New Jersey
Smart & Biggar
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