Methods of administering water-soluble prodrugs of propofol...

A - Human Necessities – 61 – K

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A61K 31/661 (2006.01) A61K 9/28 (2006.01) A61K 9/52 (2006.01)

Patent

CA 2548216

A method of administering a prodrug of propofol, preferably O- phosphonooxymethyl propofol disodium salt, comprises the oral, intragastric, or intraintestinal administration of the prodrug in amounts sufficient to induce or maintain a generalized anesthetized state, a conscious sedated state, or to treat insomnia, anxiety, nausea, vomiting, pruritus, epilepsy, and a range of pain syndromes and other medical conditions.

L'invention concerne un procédé pour administrer un promédicament de propofol, de préférence un sel de disodium de propofol de O-phosphonooxyméthyle, comprenant l'administration orale, gastrique, ou intestinale du promédicament dans des quantités suffisantes, permettant d'induire ou de maintenir un état d'anesthésie générale, un état sédatif conscient. Le promédicament peut être également utilisé pour traiter l'insomnie, l'anxiété, la nausée, les vomissements, le prurit, l'épilepsie, et des catégories de syndromes de douleurs ou d'autres états pathologiques médicaux.

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