Methods of alleviating neuropathic pain using...

Details Methods of alleviating neuropathic pain using... Methods of alleviating neuropathic pain using...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/08 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2248139

The invention provides a method of alleviating or preventing neuropathic pain in a subject by administering an effective amount of an active fragment of prosaposin to the subject. The invention also provides prosaposin-derived fragments and the use of these fragments for stimulating neurite outgrowth, inhibiting neural cell death, promoting myelination and inhibiting demyelination. In addition, there is provided a method of inhibiting sensory or motor neuropathy by contacting neuronal cells with a composition comprising an effective amount of an active fragment of prosaposin.

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