Methods of altering cardiac cell phenotype

Details Methods of altering cardiac cell phenotype Methods of altering cardiac cell phenotype

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61K 38/27 (2006.01)

Patent

CA 2329934

Methods for improving or maintaining cardiac function in patients are disclosed. The methods include the stimulation of heart muscle regeneration, the treatment of patients with congestive heart failure and the prevention of organ transplant rejection. Methods are also disclosed for the treatment of patients after myocardial infarction and/or patients with congestive heart failure by adenovirus-mediated delivery of peptides, including, but not limited to, NKX-2.5, MEF2, GATA4, BCL-2, HGH, and Fas ligand, that alter the phenotype of cells in the heart.

L'invention porte sur des procédés d'amélioration ou de maintien des fonctions du coeur chez un patient consistant à stimuler la régénération du muscle cardiaque, à traiter l'insuffisance cardiaque, et à prévenir les rejets d'organes transplantés. Elle porte également sur des procédés de traitement des patients après un infarctus du myocarde et/ou en cas d'insuffisance cardiaque par administration induite par adénovirus de peptides tels que non exclusivement le NKX-2.5, le MEF2, le GATA4, le BCL-2, le HGC et le ligand du Fas, qui modifient le phénotype des cellules cardiaques.

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