Methods of assaying receptor activity and constructs useful...

Details Methods of assaying receptor activity and constructs useful... Methods of assaying receptor activity and constructs useful...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 11/00 (2006.01) C12N 15/12 (2006.01) C40B 30/04 (2006.01) G01N 33/567 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2305810

Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. Constructs useful in such methods are described.

L'invention concerne des procédés de détection in vivo et in vitro de l'activité de récepteurs couplés à la protéine G (GPCR), des procédés d'analyse de l'activité de GPCR, et des procédés de détection des ligands de GPCR, de l'activité des kinases réceptrices couplées à la protéine G (GRK) et des composés qui interagissent avec des composants du processus régulateur de GPCR. L'invention concerne également des produits de recombinaison utiles dans de tels procédés.

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