Methods of assessing a tissue inflammatory response using...

Details Methods of assessing a tissue inflammatory response using... Methods of assessing a tissue inflammatory response using...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2551677

The invention provides methods of assessing a tissue inflammatory response, comprising making a quantitative determination of the level of at least five transcripts shown in Table 1, or proteins encoded thereby, in a sample; and comparing the abundance of said transcripts or proteins so determined with the level of said transcript obtained from a control sample. Methods for diagnosis of a condition with which a tissue inflammatory response is associated are also provided, as are gene chip arrays and protein based assays suitable for use in these methods. Assay methods for determining a modulator of a tissue inflammatory response or a condition associated therewith also form part of the invention.

L'invention concerne des procédés d'évaluation d'une réponse inflammatoire tissulaire, qui consistent à effectuer une détermination quantitative du niveau d'au moins cinq transcrits indiqués dans le Tableau 1, ou des protéines codées par ceux-ci, dans un échantillon; et à comparer l'abondance de ces transcrits ou protéines ainsi déterminés au niveau du transcrit obtenu de l'échantillon témoin. L'invention concerne en outre des procédés de diagnostic d'un état associé à une réponse inflammatoire tissulaire, ainsi que des réseaux de puces à ADN et des analyses à base de protéines que l'on peut utiliser dans ces procédés. L'invention concerne enfin des procédés d'analyse permettant de déterminer un modulateur d'une réponse inflammatoire tissulaire ou d'un état qui lui est associé.

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