Methods of assessing endothelial dysfunction using acute...

G - Physics – 01 – N

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G01N 33/53 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2498803

The present invention provides methods utilizing the fat-induced antibody response (FIAR) to assess endothelial function. Additional methods are provided that utilize FIAR for diagnosing and monitoring the progression of vascular diseases, the success of treatment for these diseases, and as a measure of the oxidative stress imposed upon vascular endothelium. Still more methods are provided for measuring the oxidation products of lipids in blood following the administration of a polyunsaturated fatty acid (fat-induced acute response) to monitor the treatment success of a vascular disease, for monitoring the degree of endothelial inflammation, and for diagnosing and monitoring the progression of a cardiovascular disease.

L'invention concerne des procédés mettant en oeuvre la réponse anticorps induite par un corps gras (FIAR) afin d'évaluer la fonction endothéliale. L'invention concerne d'autres procédés qui mettent en oeuvre la réponse FIAR afin de diagnostiquer et de surveiller la progression de maladies vasculaires, la réussite du traitement de ces maladies, et en tant que mesure du stress oxydatif imposé après l'endothélium vasculaire. L'invention concerne en outre d'autres procédés permettant de mesurer les produits d'oxydation de lipides dans le sang à la suite d'une administration d'un acide gras polyinsaturé (réponse aiguë induite par un corps gras) afin de surveiller la réussite du traitement d'une maladie vasculaire, des procédés permettant de surveiller le degré d'inflammation endothéliale, et des procédés permettant de diagnostiquer et de surveiller la progression d'une maladie cardiovasculaire.

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