C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/74 (2006.01) C07K 16/18 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2229938
The present invention provides methods for treating autoimmune diseases in mammals and for preventing or treating transplantation rejection in a transplant recipient. The methods of treatment involve the use of drugs capable of suppressing expression of MHC Class I molecules. In particular the use of the drug methimazole to suppress expression of MHC Class I molecules in the treatment of autoimmune diseases and the prevention or treatment of rejection in a transplant recipient is disclosed. In addition in vivo and in vitro assays are provided for the assessment and development of drugs capable of suppressing MHC Class I molecules. In addition, this invention relates to nucleic acid and amino acid sequences for proteins capable of modulating MHC Class I expression.
L'invention concerne des procédés relatifs aux traitements des affections auto-immunes chez les mammifères ainsi qu'à la prévention ou aux traitements des rejets de greffe chez un receveur. Les procédés de traitement font intervenir des médicaments capables de supprimer l'expression des molécules du complexe majeur d'histocompatibilité (CMH) dans la classe I. On décrit en particulier l'utilisation d'un médicament, la méthizamole afin de supprimer l'expression des molécules sus-mentionnées dans le traitement des affections auto-immunes ainsi que pour la prévention ou le traitement des rejets de greffe chez un receveur. Par ailleurs, des dosages d'analyse in vivo et in vitro sont fournis pour la détermination et l'élaboration de médicaments capables de supprimer lesdites molécules. On décrit aussi les séquences nucléotidiques et les séquences d'acides aminés concernant des protéines capables de moduler l'expression du CMH en classe I.
Giuliani Cesidio
Kohn Leonard
Ohmori Masayuki
Saji Motoyasu
Shong Minho
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Smart & Biggar
The Government Of The United States Of America As Represented By Department Of Health And Human Services
LandOfFree
Methods of assessing mhc class i expression and proteins... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of assessing mhc class i expression and proteins..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of assessing mhc class i expression and proteins... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1428267