Methods of blocking tissue destruction by autoreactive t cells

A - Human Necessities – 61 – K

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Details

A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 45/00 (2006.01) C07K 4/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01) A61K 38/11 (2006.01)

Patent

CA 2404340

Methods for blocking autoreactive T cell-initiated destruction of tissues in a mammal are provided. In one embodiment, the method comprises administering a pharmaceutical composition comprising a biologically effective amount of an isolated and purified CD24 polypeptide, or a fusion protein comprising such polypeptide to a mammalian subject who is suspected of having an autoimmune disease. In another embodiment, the method comprises administering a pharmaceutical composition comprising a biologically effective amount of an anti- CD24 antibody or anti- CD24 Fab fragments to the subject. The present invention also relates to isolated and purified CD24 fusion proteins employed in the present methods and to transgenic mice that express the human CD24 protein on their T cells and/or their vascular endothelial cells but do not express murine heat shock antigen on any cells.

L'invention concerne des procédés permettant d'inhiber la destruction des tissus par des lymphocytes T autoréactifs chez un mammifère. Dans un mode de réalisation, le procédé consiste à administrer une composition pharmaceutique comprenant une quantité biologiquement efficace d'un polypeptide CD24 purifié ou isolé, ou une protéine hybride contenant un tel polypeptide à un sujet mammifère pouvant être atteint d'une maladie auto-immune. Dans un autre mode de réalisation, le procédé consiste à administrer une composition pharmaceutique comprenant une quantité biologiquement efficace d'un anticorps anti-CD24 ou d'un fragment Fab anti- CD24 au patient. La présente invention concerne également des protéines hybrides CD24 purifiées et isolées utilisées pour mettre en oeuvre les procédés susmentionnés, ainsi que des souris transgéniques qui présentent l'expression de la protéine CD24 humaine sur leurs lymphocytes T et/ou sur leurs cellules endothéliales mais qui ne présentent l'expression de l'antigène de choc thermique murin sur aucune cellule.

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