Methods of cancer diagnosis using a chimeric toxin

Details Methods of cancer diagnosis using a chimeric toxin Methods of cancer diagnosis using a chimeric toxin

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 7/23 (2006.01) C07K 14/21 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2323786

The present invention relates to methods for cancer diagnosis using a chimeric toxin. In particular, the invention relates to the use of a chimeric toxin composed of gonadotropin releasing hormone (GnRH) and Pseudomonas exotoxin A (PE) to detect a tumor-associated epitope expressed by human adenocarcinomas. Mutated GnRH-PE molecules that bind but do not kill tumor cells are exemplified.

L'invention concerne des procédés servant à diagnostiquer le cancer au moyen d'une toxine chimère. Elle concerne, en particulier, l'utilisation d'une toxine chimère composée d'une hormone de libération de gonadotrophine (GnRH) et d'une exotoxine A de Pseudomonas (PE) afin de détecter un déterminant antigénique associé à une tumeur et exprimé par des adénocarcinomes humains. Elle cite pour exemple des molécules de GnRH-PE ayant subi une mutation et qui se fixent aux cellules cancéreuses sans les détruire.

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