Methods of cardiovascular disease assessment in an individual

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G01N 1/00 (2006.01) G01N 33/48 (2006.01)

Patent

CA 2498329

Methods for cardiovascular disease assessment in an individual comprise detecting the presence or absence of a fragment encoding a polymorphic alpha- 2C (.alpha.2C DEL322-325) adrenergic receptor in a sample from an individual; and detecting the presence or absence of a fragment encoding a polymorphic beta-1 adrenergic receptor (.beta.1Arg389) in a sample from the individual. Methods for delaying development of cardiovascular disease in an individual, methods for delaying progression or early death associated with cardiovascular disease in an individual, methods of genetic counseling for cardiovascular disease in an individual are also provided.

La présente invention concerne des procédés d'évaluation de maladie cardiovasculaire chez un individu, selon lesquels on détecte la présence ou l'absence d'un fragment codant un récepteur adrénergique alpha-2C (.alpha.¿2C? DEL322-325) polymorphe dans un prélèvement effectué chez un individu, et on détecte la présence ou l'absence d'un fragment codant un récepteur adrénergique beta-1 (.beta.¿1?Arg389) polymorphe dans un prélèvement effectué chez l'individu. L'invention se rapporte également à des procédés qui permettent de retarder le développement d'une maladie cardiovasculaire chez un individu, à des procédés qui permettent de retarder la progression d'une maladie cardiovasculaire ou la mort précoce associée à une maladie cardiovasculaire chez un individu, et à des procédés de conseil génétique lié aux maladies cardiovasculaires chez un individu.

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