Methods of characterizing drug activities using consensus...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2356648

The present invention provides methods for enhanced detection of biological response profiles. In particular, the methods of this invention allow for the detection of biological response patterns, such as gene expression patterns, in response to different drug treatments. The methods of the invention also allow the determination of a "consensus profile" which describes a particular class or type of biological response. In certain embodiments the consensus profile may describe the biological response of a particular group or class of drugs. In other embodiments, the consensus profile may describe an "ideal" biological response such as one associated with a desired therapeutic effect. The methods of the present invention also allow for the comparison of different biological responses. Thus, the methods of the invention may be used, e.g., to identify and/or study new drugs.

La présente invention concerne des procédés destinés à la détection améliorée de profils de réponses biologiques. En particulier, les procédés de cette invention permettent de détecter des motifs de réponses biologiques, tels que des motifs d'expression de gènes, en réponse à différents traitements médicamenteux. Ces procédés permettent aussi de déterminer un <= profil de consensus >= quidécrit une classe ou un type particulier de réponse biologique. Dans certaines réalisations, le profil de consensus peut décrire la réponse biologique d'un groupe ou d'une classe particulière de médicaments. Dans d'autres réalisations, le profil de consensus peut décrire une réponse biologique <= idéale >= telle que celle associée à un effet thérapeutique désiré. Les procédés de la présente invention permettent aussi de comparer des réponses biologiques différentes. Ainsi, ces procédés peuvent être utilisés, par exemple, afin d'identifier et/ou d'étudier de nouveaux médicaments.

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