Methods of compositions for normalizing lipid levels in...

Details Methods of compositions for normalizing lipid levels in... Methods of compositions for normalizing lipid levels in...

A - Human Necessities

61

K

A61K 38/23 (2006.01) A61K 38/22 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 5/06 (2006.01) A61P 9/12 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2471833

The invention provides methods of stimulating lipolysis in a mammalian cells and tissues by contacting the cell or tissue with an agonist of a CGRP receptor such as the high affinity CGRP receptor. The agonist may preferentially stimulate the high affinity CGRP receptor compared to the metabolic amylin receptor. Methods for screening for identifying receptor agonists are provided, pharmaceutical compositions comprising such agonists, and therapeutic regimens using such agonists are provided.

L'invention concerne des procédés permettant de stimuler la lipolyse dans des cellules et tissus mammaliens par contact de la cellule ou du tissu avec un agoniste d'un récepteur de CGRP, par exemple le récepteur de CGRP à affinité élevée. L'agoniste peut, de préférence, stimuler le récepteur CGRP à affinité élevée en comparaison avec le récepteur d'amyline métabolique. L'invention concerne également des procédés de criblage permettant d'identifier des agonistes de récepteur, des compositions renfermant de tels agonistes et des schémas thérapeutiques faisant appel à de tels agonistes.

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