Methods of constructing biodiverse gene fragment libraries...

Details Methods of constructing biodiverse gene fragment libraries... Methods of constructing biodiverse gene fragment libraries...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 38/02 (2006.01) C07K 7/04 (2006.01) C07K 14/00 (2006.01) C07K 14/195 (2006.01) C12N 15/31 (2006.01) C40B 40/02 (2006.01) C40B 50/06 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2516284

Methods for producing nucleic acid fragment libraries that express highly diverse peptide domains, wherein the nucleic acid fragments are derived form microorganisms or eukaryotes with compact genomes. Also peptides derived form the libraries wherein the peptides are selected on the basis of their abilities to bind selected target proteins, including c-jun and antibodies raised against dust mite allergens.

L~invention concerne des méthodes pour produire des banques de fragments d~acides nucléiques exprimant des domaines peptidiques très divers, les fragments d~acides nucléiques étant dérivés de micro-organismes ou d~eucaryotes à génomes compacts. L~invention concerne également des peptides dérivés de ces banques et sélectionnés sur la base de leurs aptitudes à fixer des protéines cibles choisies, notamment des c-jun et des anticorps dressés contre les allergènes du type acarien détriticole.

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