Methods of controlling axonal growth

Details Methods of controlling axonal growth Methods of controlling axonal growth

A - Human Necessities

61

K

A61K 38/17 (2006.01)

Patent

CA 2295500

Agents which modulate a bcl family member to control axonal growth and regeneration are described. These bcl modulating agents promote axonal growth and regeneration in the neural cells of a subject. Compositions for promoting axonal cell growth in a subject also are described. The compositions of the present invention include an effective amount of an agent which modulates a bcl family member and in a pharmaceutically acceptable carrier. Other described aspects include packaged drugs for treating a state characterized by diminished potential for axonal growth. The packaged compounds and agents also include instructions for using the agent to promote axonal growth in a subject.

L'invention décrit des agents qui modulent un membre de la famille .beta.?.lambda. afin de réguler la régénération et la croissance axonale. Ces agents de modulation bcl favorisent la régénération et la croissance axonales dans les cellules neurales d'un sujet. Des compositions favorisant la croissance des cellules axonales chez un sujet sont également décrites. Les compositions de la présente invention comprennent une quantité efficace d'un agent qui module un élément de la famille bcl et dans un support pharmaceutiquement acceptable. D'autres aspects de l'invention concernent des médicaments conditionnés pour traiter un état caractérisé par un potentiel réduit de la croissance axonale. Les composés conditionnés et les agents incluent également des instructions d'utilisation de l'agent afin de favoriser la croissance axonale chez un sujet.

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