C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2344653
A method of expanding a population of cells, while at the same time inhibiting differentiation of the cells, the method includes the step of providing the cells with conditions for cell proliferation and, at the same time, for reducing a capacity of the cells in utilizing copper. The method can be executed both in-vivo and ex-vivo. A method of inducing differentiation in a population of cells, the method includes the step of providing the cells with a transition metal chelator which binds copper and which is effective in inducing cell differentiation.
Ce procédé d'accroissement d'une population de cellules, en même temps qu'il inhibe la différentiation des cellules, comprend l'étape consistant à mettre les cellules dans des conditions leur permettant de proliférer et simultanément à réduire la capacité de celles-ci d'utiliser du cuivre, ce procédé pouvant s'exécuter à la fois in vivo et ex vivo. L'invention concerne également un procédé d'induction de la différentiation dans une population de cellules, comprenant l'étape consistant à fournir aux cellules un chélateur métallique de transition, lequel se lie au cuivre et est efficace pour induire la différentiation cellulaire.
Fibach Eitan
Peled Tony
Treves Avi
Gamida Cell Ltd.
Hadasit Medical Research & Development Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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