Methods of conversion of interferon isoforms and products...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2348739

The present invention provides methods for isolating adjunct isoforms of proteins and converting them to the desired protein. In preferred embodiments, the present invention contemplates the use of acid solutions or zinc solutions to cleave a chemical group from a desired protein. In further preferred embodiments, the present invention contemplates the oxidation of reduced sulfhydryl groups with cleavage of chemical groups to form a functional desired protein.

La présente invention concerne des méthodes permettant d'isoler des isoformes apparentées de protéines et de les transformer en une protéine souhaitée. Selon les modes de réalisation préférés, la présente invention concerne l'utilisation de solutions acides ou de solutions de zinc pour cliver un groupe chimique d'une protéine souhaitée. Selon d'autres modes de réalisation préférés, la présente invention concerne l'oxydation de groupes sulfhydryle réduits avec clivage de groupes chimiques de manière à former une protéine fonctionnelle souhaitée.

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