C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/02 (2006.01) C07K 16/00 (2006.01) C12N 5/00 (2006.01) C12N 15/09 (2006.01) C12P 21/02 (2006.01) C12P 21/04 (2006.01) C12P 21/06 (2006.01)
Patent
CA 2447791
A method of improving expression of polypeptides in mammalian cell culture systems is provided. In particular, the invention is directed to methods of culturing mammalian cells under conditions such as, for example, high levels of glucose, where environmental and nutritional conditions are controlled and adjusted so as to improve process robustness and to promote superior expression of polypeptides having desired qualities, e.g., biological activity. The invention also relates to polypeptides, especially antibodies, produced by the methods, and to methods of using such antibodies, and to pharmaceutical compositions containing the polypeptides. The invention also relates to methods of culturing animal cells in a fed batch cell culture to maximize production capacity, viability of the cell culture, and overall enhancement of yield from such cultures.
L'invention porte sur un procédé visant à améliorer l'expression de polypeptides dans des systèmes de culture de cellules mammaliennes. L'invention porte notamment sur des procédés de mise en culture de cellules mammaliennes dans des conditions où l'on observe des taux de glucose élevés, les conditions environnementales et nutritionnelles étant régulées et ajustées de manière à améliorer la robustesse du processus et à améliorer l'expression des polypeptides ayant des qualités désirées telles que leur activité biologique. L'invention porte également sur des polypeptides, notamment des anticorps, produits par ces procédés, et sur des procédés d'utilisation de ces anticorps ainsi que sur des compositions pharmaceutiques contenant les polypeptides. L'invention porte sur des procédés de mise en culture de cellules animales dans une culture cellulaire semi-discontinue afin de maximiser la capacité de production, la viabilité de la culture cellulaire et d'accroître globalement le rendement de ces cultures.
Delacruz Neslihan
Etcheverry Tina
Ostland Michael
Genentech Inc.
Smart & Biggar
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