Methods of delivering anti-restenotic agents from a stent

A - Human Necessities – 61 – F

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A61F 2/06 (2006.01)

Patent

CA 2525393

A method for decreasing the level of restenosis following a stent (10) placement medical intervention involves the continuous administration of a dose of an anti-restenotic agent, such as paclitaxel, from the stent to vascular tissue in need of treatment in a controlled, extended and substantially linear drug release profile. The method of substantially linear extended release increases the therapeutic effectiveness of administration of a given dosage. In one example, a method of reducing restenosis includes delivering paclitaxel from a stent (10) to an artery at a minimum release rate of 1 percent of the total dosage of paclitaxel on the stent (10) per day throughout an entire administration period from the time of implantation of the stent (10) until the time that substantially all the paclitaxel is released from the stent (10).

L'invention concerne un procédé destiné à diminuer le niveau de resténose à la suite d'une intervention médicale de mise en place d'une endoprothèse, qui implique l'administration continue d'une dose d'un agent anti-resténose, par exemple le paclitaxel, à partir de l'endoprothèse au tissu vasculaire nécessitant un traitement suivant un profil de libération de médicament régulée, étendue et sensiblement linéaire. Le procédé de libération étendue et sensiblement linéaire augmente l'efficacité thérapeutique d'un dosage donné. Selon un exemple, un procédé destiné à réduire la resténose consiste à administrer le paclitaxel à partir d'une endoprothèse à une artère suivant un débit de libération minimal de 1 % du dosage total par jour de paclitaxel sur l'endoprothèse pendant toute la période d'administration à partir du moment de son implantation jusqu'à celui où sensiblement tout le paclitaxel est libéré par l'endoprothèse.

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