Methods of deriving differentiated cells from stem cells

Details Methods of deriving differentiated cells from stem cells Methods of deriving differentiated cells from stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/073 (2010.01) C12N 5/071 (2010.01)

Patent

CA 2745742

The present invention provides a method of generating definitive endoderm, mesoderm, or ectoderm cells. The method includes culturing embryonic stem cells, parthenogenetic cells, or induced pluripotent stem cells in the presence of a demethylation agent, a histone deacetylase inhibitor, or a combination thereof, and thereafter, culturing the stem cells in the absence of the agent or combination of agents, to produce definitive endoderm cells, mesoderm, or ectoderm cells.

La présente invention concerne un procédé de génération de cellules dendoderme, de mésoderme, ou dectoderme définitives. Le procédé comprend la culture de cellules souches embryonnaires, de cellules parthénogénétiques, ou de cellules souches pluripotentes induites en présence dun agent de déméthylation, un inhibiteur dhistone désacétylase, ou une combinaison de ceux-ci, et ensuite, la culture des cellules souches en labsence de lagent ou combinaison dagents, pour produire des cellules dendoderme, mésoderme, ou ectoderme définitives.

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