Methods of detecting a phenotype of a polymorphic protein

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 9/10 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2573392

The present invention provides an antibody that differentially reacts with allelic variants of a polymorphic protein, methods of identifying same, an antigen binding fragment comprised therein, nucleic acids encoding same, proteins, cells, viral particles, compositions, and kits comprising same. The invention also provides methods for determining a haptoglobin type of a subject and methods for testing a subject for susceptibility to diabetic complications.

La présente invention a trait à un anticorps présentant une réaction différentielle avec des variants alléliques d'une protéine polymorphe, à des procédés d'identification d'un tel anticorps, à un fragment de liaison à l'antigène contenu dans un tel anticorps, à des acides nucléiques codant pour un tel anticorps, à des protéines, des cellules, des particules virales, des compositions, et des trousses comportant un tel anticorps. L'invention a également trait à des procédés pour la détermination d'un type d'haptoglobine d'un sujet et à des procédés pour le contrôle d'un sujet concernant la susceptibilité à des complications diabétiques.

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