Methods of detecting collagen degradation in vivo

Details Methods of detecting collagen degradation in vivo Methods of detecting collagen degradation in vivo

C - Chemistry, Metallurgy

12

P

150/11, 150/14,

C12P 21/08 (2006.01) A61K 49/00 (2006.01) C07K 5/04 (2006.01) C07K 7/06 (2006.01) C07K 16/18 (2006.01) C12N 5/18 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2031265

Methods of determining collagen degradation in viro, by quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-line or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. Suitablemethods include immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structures of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.

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