Methods of detecting, diagnosing and treating cancer and...

Details Methods of detecting, diagnosing and treating cancer and... Methods of detecting, diagnosing and treating cancer and...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2454866

Disclosed are methods, compositions and apparatus useful in the detection, monitoring and treatment of the progression of neoplasia and preneoplastic conditions with special emphasis on the chromosomal changes related to the development and progression of urothelial neoplasia. Chromosomal changes, including LOH, at the disclosed loci demonstrate a statistically significant relation to the progression of disease state in urothelial neoplasia.

L'invention concerne des procédés, des compositions et des appareils utiles pour la détection, le contrôle et le traitement de la progression d'une néoplasie et d'états prénéoplasiques, une importance particulière étant accordée aux altérations chromosomiques liées au développement et à la progression de néoplasie urothéliale. Les altérations chromosomiques, notamment la perte d'hétérozygosité (LOH), au niveau des loci décrits dans la présente invention démontrent qu'il existe un lien statistiquement significatif avec la progression de l'état de la maladie dans le cadre d'une néoplasie urothéliale.

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