C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/00 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2517452
The present invention provides methods of detecting an amyloid peptide-related neurological disorder in an individual; and methods for staging an amyloid peptide-related neurological disorder in an individual. The methods involve detecting a level of a calcium-responsive gene product, such as calbindin, in a hippocampal neuron, especially a granule cell of the dentate gyrus. The invention further provides identifying an agent that treats an amyloid peptide- related neurological disorder, as well as agents identified by the methods.
La présente invention concerne des méthodes de détection d'un trouble neurologique associé au peptide amyloïde chez un individu, ainsi que des méthodes de stadification d'un trouble neurologique associé au peptide amyloïde chez un individu. Ces méthodes consistent à détecter un taux d'un produit génique sensible au calcium, tel que la calbindine, dans un neurone hyppocampique, et notamment une cellule granulaire du gyrus denté. L'invention concerne également l'identification d'un agent permettant de traiter un trouble neurologique associé au peptide amyloïde, ainsi que des agents identifiés au moyen de ces méthodes.
Mucke Lennart
Palop Jorge J.
Fetherstonhaugh & Co.
The J. David Gladstone Institutes
The Regents Of The University Of California
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