Methods of detecting prion protein

Details Methods of detecting prion protein Methods of detecting prion protein

G - Physics

01

N

G01N 33/68 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2437999

The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases involving polypeptide aggregation such as prion infections. The methods of the invention first block accessible polypeptide target epitope with a protecting agent. After denaturation of the polyeptide, a detecting agent is used to detect protein with target epitope that was inaccessible during contact with the protecting agent.

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