B - Operations – Transporting – 01 – D
Patent
B - Operations, Transporting
01
D
B01D 59/44 (2006.01) C12Q 1/48 (2006.01) G01N 33/68 (2006.01) G01N 30/72 (2006.01)
Patent
CA 2447336
This invention relates to methods and reagents for detecting the presence of symmetrically and asymmetrically methylated arginine residues, either along or in polypeptides, using mass spectrometry. It also provides methods of determining structures of methylated arginine residues, methods of identifying substrates of PMRTs, and methods of conducting proteomic business using any of the suitable methods recited above.
La présente invention concerne des procédés et des réactifs de détection par spectrométrie de masse de la présence de résidus d'arginine méthylée de façon symétrique ou asymétrique accompagnant des polypeptides ou présents dans ces polypeptides. L'invention concerne également des procédés permettant de déterminer les structures des résidus d'arginine méthylée, des procédés permettant d'identifier des substrats de PMRT (méthyltransférase d'arginine), ainsi que des procédés permettant de mener des recherches protéomiques mettant en oeuvre l'un des procédés de l'invention.
Brame Cynthia J.
Mcbroom Linda
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Mds Proteomics Inc.
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