G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 27/62 (2006.01)
Patent
CA 2743907
Disclosed herein are methods of determining polydispersity (PDI) and molecular mass distribution (MMD) of reactive PEG samples using mass spectrometry. More specifically, a mass spectrometry method called GEMMA is used to determine PDI and MMD of PEG samples which provides more accurate measurements for high molecular weight PEG samples than prior known MALDI-TOF analysis.
La présente invention concerne des méthodes de détermination de la polydispersité (PDI) et de la distribution de masse moléculaire (MMD) d'échantillons de PEG réactif qui reposent sur la spectrométrie de masse. L'invention concerne plus particulièrement une méthode de spectrométrie de masse désignée GEMMA qui est utilisée pour déterminer la PDI et la MMD d'échantillons de PEG et qui offre des mesures plus précises que l'analyse MALDI-TOF classique pour les échantillons de PEG de haut poids moléculaire.
Allmaier Guenter
Kemptner Jasmin
Marchetti-Deschmann Martina
Schwarz Hans-Peter
Siekmann Juergen
Baxter Healthcare S.a.
Baxter International Inc.
Sim & Mcburney
Technische Universitaet Wien
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